From Rome: highway A1, exit Frosinone in direction Sora P.N.A; take highway A24-25 exit Aielli towards Pescasseroli P.N.A.

From Pescara: Highway A25 exit Pratola , follow Sulmona, Castel di Sangro, towards P.N.A.

From Naples: Highway A1 exit Caianello towards Venafro and Castel di Sangro towards P.N.A.

From Bari: Highway A14 towards Pescara, exit Valdisangri direction Castel di Sangro di Sangro towards P.N.A.